|
KMID : 0043320180410010057
|
|
Archives of Pharmacal Research
2018 Volume.41 No. 1 p.57 ~ p.63
|
|
|
Varilactones and wortmannilactones produced by Penicillium variabile cultured with histone deacetylase inhibitor
|
|
He Xueqian
Zhang Zhenzhen
Che Qian
Zhu Tianjiao
Gu Qianqun
Li Dehai
|
|
|
Abstract
|
|
|
|
Seven polyketides, including four new ones named as varilactones A?B (1?2) and wortmannilactones M?N (3?4), as well as three biogenetically related known wortmannilactones E, F and H (5?7), were isolated from the fungus Penicillium variabile HXQ-H-1, cultivated in potato-based medium with the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA). Their structures (1?7) were established by analysis of NMR and MS data, and the absolute configuration of oxabicyclo[2.2.1]heptane unit was deduced from 1H-NMR analyses on MPA esters after chemical reduction reaction. Among them, varilactones A and B (1 and 2), features a novel skeleton with a triene unit linking an oxabicyclo[2.2.1]heptane and an oxabicyclo[3.3.0]octane rings.
|
|
|
KEYWORD
|
|
|
Epigenetic modification, Penicillium variabile, Suberoylanilide hydroxamic acid, Polyketides
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|